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adcs  (ATCC)
97
ATCC adcs
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. <t>c,</t> <t>Cytotoxic</t> activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Adcs, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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adcs  (Sino Biological)
93
Sino Biological adcs
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. <t>c,</t> <t>Cytotoxic</t> activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Adcs, supplied by Sino Biological, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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semipreparative radio hplc jasco lc netii adc hplc system  (JASCO Inc)
97
JASCO Inc semipreparative radio hplc jasco lc netii adc hplc system
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. <t>c,</t> <t>Cytotoxic</t> activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Semipreparative Radio Hplc Jasco Lc Netii Adc Hplc System, supplied by JASCO Inc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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belantamab mafodotin adc  (MedChemExpress)
94
MedChemExpress belantamab mafodotin adc
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. <t>c,</t> <t>Cytotoxic</t> activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Belantamab Mafodotin Adc, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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automatic development chamber 2 adc 2  (Camag)
86
Camag automatic development chamber 2 adc 2
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. <t>c,</t> <t>Cytotoxic</t> activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Automatic Development Chamber 2 Adc 2, supplied by Camag, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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adc protein  (Amgen)
86
Amgen adc protein
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. <t>c,</t> <t>Cytotoxic</t> activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Adc Protein, supplied by Amgen, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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chamber adc 2  (Camag)
86
Camag chamber adc 2
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. <t>c,</t> <t>Cytotoxic</t> activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Chamber Adc 2, supplied by Camag, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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adcs  (Biacore)
86
Biacore adcs
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. <t>c,</t> <t>Cytotoxic</t> activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Adcs, supplied by Biacore, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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l1cam adc  (Charles River Laboratories)
86
Charles River Laboratories l1cam adc
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. <t>c,</t> <t>Cytotoxic</t> activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
L1cam Adc, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. c, Cytotoxic activity of ADCs in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.

Journal: bioRxiv

Article Title: De novo masking domains that gate TNF-family ligand assembly and activity

doi: 10.64898/2026.04.20.719557

Figure Lengend Snippet: The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. c, Cytotoxic activity of ADCs in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.

Article Snippet: Cytotoxic activity of ADCs was evaluated using SK-BR-3 human breast cancer cells (ATCC).

Techniques: Binding Assay, Isolation, Activation Assay, Construct, Functional Assay, In-Cell ELISA, Activity Assay, Control